Famous film director Guido Contini (Daniel Day-Lewis) struggles to find harmony in his professional and personal lives, as he engages in dramatic relationships with his wife (Marion Cotillard), his mistress (Penélope Cruz), his muse (Nicole Kidman) and his mother (Sophia Loren). A reporter (Kate Hudson), a colleague (Judi Dench) and a whore (Fergie) are also other women in the life of Guido.
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