After a string of robberies that left a river of blood, two sadistic siblings named Seth and Richie Gecko head to Mexico running away from the FBI. To get over the border, they kidnap Jacob Fuller, a widowed preacher (Harvey Keitel), and his two children, Kate (Juliette Lewis) and Scott (Ernest Liu). Once south of the border, the quintet park their RV at a rough-and-tumble trucker bar called The Titty Twister, where Seth and Richie are supposed to meet a local thug. After a couple of drinks, they realize that they're not in a typical bar, as the entire place begins to teem with vicious, blood-sucking vampires. With the odds stacked greatly against them, the Fullers and Geckos team together in hopes of defeating the creatures of the night.
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