Two potheads, Jesse (Ashton Kutcher) and Chaster (Seann William Scott) wake up one morning with no recollection of the previous night and their car missing. After discovering their stash of drugs is gone, they go in search of more. Meanwhile their girlfriends are holding a grudge because Jesse and Chester have forgotten their anniversary. While their search continues, Jesse and Chester soon discover what really happened the night before which includes a suitcase full of money, a gorgeous gender-challenged stripper, six alien women and an intergalactic war.
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